Gastroenterology Summaries
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889
— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…
Therapeutic food supplements that promote healthy gut microbiome to treat malnutritionBarratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889
— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…
Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infectionCrowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079
— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …
Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infectionCrowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079
— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …
Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imagingChapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449
— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…
Intestinal biomarker predicts response to treatment for inflammatory bowel diseaseStappenbeck, Thaddeus ; VanDussen, Kelli
T-019186
— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…
Method to evaluate function of members of a gut microbiotaGordon, Jeffrey ; Patnode, Michael
T-018760
— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…
SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditionsCloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895
— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …
Nano-CaCO3Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910
— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesDeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
Inflammatory bowel disease biomarkers and therapeutic targetKaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesDeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
Anti-fungal treatment and companion diagnostic for Crohn’s DiseaseJain, Umang ; Stappenbeck, Thaddeus
T-019293
— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…
Inflammatory bowel disease biomarkers and therapeutic targetKaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Method to characterize gut microbiomeGordon, Jeffrey ; Raman, Arjun
T-018977
— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…
Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritisFinkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294
— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…
